Human pluripotent stem cells are slowly but steadily transitioning from bench to bedside, with the first clinical trials showing promising results. Nevertheless, the spectrum of potentially treatable conditions is still limited, and issues such as genome instability and suboptimal differentiation are significant hurdles to the safe transition of these cells to the clinic.
This Special Issue welcomes manuscripts providing insight on aspects relevant to the use of hPSC in regenerative medicine. We are interested in a wide range of work, including differentiation to novel cell types or improvement on existing cell types, and their preclinical testing. Work on biomaterials and scaffolding, with an eye for tissue engineering are also key for advanced hPSC-based therapy. Finally, work on safety, such as addressing the tumorigenic potential of hPSC-derived products, and scalability aspects, such as cell culture, are essential for the successful clinical application of these cells.
Prof. Dr. Claudia Spits
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