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Karen Sermon

After her medical degree at the VUB, Karen Sermon started her scientific career first as a master, then as a PhD student with Inge Liebaers and André Van Steirteghem. The topic of her PhD was the development of a preimplantation genetic diagnosis (PGD) for Tay-Sachs disease. In the years following her PhD degree, she was instrumental in developing PGD for monogenic diseases at the Centres for Medical Genetics and Reproductive Medicine, leading to nearly 60 highly cited papers on the subject. The PGD clinic today at the UZ Brussel is one of the largest in the world. Karen Sermon has also been very active in the European Society for Human Reproduction and Embryology (https://www.eshre.eu), as a coordinator for the special interest groups “reproduction and genetics”, and later “stem cells”. She was also one of the founders of the ESHRE PGD Consortium (https://www.eshre.eu/Data-collection-and-research/Consortia/PGD-Consortium.aspx) which still today is an important source of information on the daily practice of PGD, and an influential voice in policy making at different levels. Currently, she is a member of the Executive Committee of ESHRE (https://www.eshre.eu/Home/Committees/Executive-Committee.aspx)

Currently, Karen Sermon has research projects in the field of human pluripotent stem cells and in reproductive genetics, more precisely in the origin of chromosomal abnormalities in human embryos.

MYOTONIC DYSTROPHY TYPE I

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ANEUPLOIDY IN HUMAN DEVELOPMENT

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DIFFERENTIATION BIAS IN HPSC

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DIFFERENT SOURCES OF HPSC

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PhDs

Ongoing

HAMIDE YILDIRIM. Since December 2019: PhD project: Functional characterization of genes associated with MCD

NUŠA KRIVEC. Since May 2019. PhD project: Mechanisms regulating exit from pluripotency

MARIUS REGIN. Since August 2018. PhD project: Aneuploidy in early human development

EDOUARD COUVREU DE DECKERSBERG. Since July 2018 PhD project: Genome integrity in hPSC.

 

Graduated

SILVIE FRANCK. Public defence march 2021. PhD dissertation: The molecular basis of an expandable gene: Focus on DM1

DOMINIKA DZIEDZICKA. Public defence 2020. PhD dissertation: Differentiation propensity of human embryonic stem cell lines: assays and molecular mechanisms

LISE BARBE. Public defence 2017. PhD dissertation: Identification of molecular key drivers in disease development in myotpnic dystrophy type I

VEERLE GOOSSENS. Public defence 2015. PhD dissertation: Preimplantation genetic diagnosis. From bench to data collection. Co-promotor with Joep Geraedts en Sjoerd Repping

AFRODITI MERTZANIDOU. Public defence 2015. PhD dissertation: Chromosomal abnormalities in human preimplantation development. Co-promotor with Claudia Spits

KURT JACOBS. Public defence 2015. PhD dissertation: Genomic integrity of human embryonic stem cells: Low grade mosaicism and the effect of culture density. Co-promotor with Claudia Spits

LINDSEY VAN HAUTE. Public defence 2013. PhD dissertation: Human embryonic stem cells as a paradigm for disease modelling in respiration. Co-promotor Martine De Rycke

CHEN BING. Public defence 2011. PhD dissertation: Extracellular factors regulate pancreatic fate of human embryonic stem cells. Co-promotor with Luc Bouwens

ILEANA MATEIZEL. Public defence 2010. PhD dissertation: Human embryonic stem cells: challenges and novel approaches. Co-promotors Inge Liebaers and André Van Steirteghem

URIELLE ULLMANN. Public defence 2009. PhD dissertation: Human embryonic stem cell derivation and optimization of cultures: characterisation of epithelial-mesenchymal transition in feeder free cultures. Co-promotor with Inge Liebaers and Martine De Rycke

NELE DE TEMMERMANN. Public defence 2009. PhD dissertation: DM1 repeat instability in human gametes, embryos and embryonic stem cells. Co-promotor with Inge Liebaers

CLAUDIA SPITS. Public defence 2006. PhD dissertation: (R)evolution in preimplantation genetic diagnosis: development and clinical application of different approaches to preimplantation genetic diagnosis for monogenic disorders. Co-promoter with Inge Liebaers

 

Links to public databases

All Karen Sermon's publications can be found here:

ResearcherID

Web of Knowledge

Researchgate

All Karen Sermon's supervised masters and PhDs can be found here.

This includes PhD theses outside REGE where she was a jury member.

Recent publications

Sustained intrinsic WNT and BMP4 activation impairs hESC differentiation to definitive endoderm and drives the cells towards extra-embryonic mesoderm

15/04/2021
Sustained intrinsic WNT and BMP4 activation impairs hESC differentiation to definitive endoderm and drives the cells towards extra-embryonic mesoderm Markouli, C., Couvreu De Deckersberg, E. , Dziedzicka, D. A., Regin, M. , Franck, S., Keller, A. S., Gheldof, A. , Geens, M. , Sermon, K. & Spits...

Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm

17/03/2021
Endogenous suppression of WNT signalling in human embryonic stem cells leads to low differentiation propensity towards definitive endoderm Dziedzicka, D., Tewary, M., Keller, A., Tilleman, L., Prochazka, L., Östblom, J., Couvreu De Deckersberg, E. , Markouli, C., Franck, S., Van Nieuwerburgh, F.,...

MSH2 knock-down shows CTG repeat stability and concomitant upstream demethylation at the DMPK locus in myotonic dystrophy type 1 human embryonic stem cells

06/01/2021
MSH2 knock-down shows CTG repeat stability and concomitant upstream demethylation at the DMPK locus in myotonic dystrophy type 1 human embryonic stem cells Franck, S., Barbé, L., Ardui, S., De Vlaeminck, Y. , Allemeersch, J., Dziedzicka, D., Spits, C. , Vanroye, F., Hilven, P. , Duqué, G.,...

Trophectoderm specification: compaction, polarisation and inner and outer cells occur simultaneously in the human preimplantation embryo

01/07/2020
Trophectoderm specification: compaction, polarisation and inner and outer cells occur simultaneously in the human preimplantation embryo Demtschenko, A. , Essahib, W. , Verheyen, G. , Sermon, K. , Tournaye, H. & Van De Velde, H. , Jul 2020 , In : Human Reproduction. 35 , suppl 1 O-230 , p. 102-...

The involvement of MAN2C1 in the development of cortical malformations

06/06/2020
The involvement of MAN2C1 in the development of cortical malformations Kerkhove, L. , Yildirim, H. , Seneca, S. , Gheldof, A. , Dumitriu, D., Sermon, K. , Jansen, A. , Nassogne, M-C. & Stouffs, K. , 6 Jun 2020 .

Research output : Unpublished contribution to conference › Poster...