Karen Sermon

After her medical degree at the VUB, Karen Sermon started her scientific career first as a master, then as a PhD student with Inge Liebaers and André Van Steirteghem. The topic of her PhD was the development of a preimplantation genetic diagnosis (PGD) for Tay-Sachs disease. In the years following her PhD degree, she was instrumental in developing PGD for monogenic diseases at the Centres for Medical Genetics and Reproductive Medicine, leading to nearly 60 highly cited papers on the subject. The PGD clinic today at the UZ Brussel is one of the largest in the world. Karen Sermon has also been very active in the European Society for Human Reproduction and Embryology (https://www.eshre.eu), as a coordinator for the special interest groups “reproduction and genetics”, and later “stem cells”. She was also one of the founders of the ESHRE PGD Consortium (https://www.eshre.eu/Data-collection-and-research/Consortia/PGD-Consortium.aspx) which still today is an important source of information on the daily practice of PGD, and an influential voice in policy making at different levels. Currently, she is a member of the Executive Committee of ESHRE (https://www.eshre.eu/Home/Committees/Executive-Committee.aspx)

Currently, Karen Sermon has research projects in the field of human pluripotent stem cells and in reproductive genetics, more precisely in the origin of chromosomal abnormalities in human embryos.

MYOTONIC DYSTROPHY TYPE I

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ANEUPLOIDY IN HUMAN DEVELOPMENT

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DIFFERENTIATION BIAS IN HPSC

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DIFFERENT SOURCES OF HPSC

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PhDs

Ongoing

MARIUS REGIN. Since August 2018. PhD project: Aneuploidy in human development

EDOUARD COUVREU DE DECKERSBERG. Since July 2018 PhD project: Genome integrity in hPSC.

ELA KACIN. Since March 2017. PhD project: Improving iPS reprogramming using oocyte-specific factors

SILVIE FRANCK. Since. PhD project: mechanisms of CTG repeat instability in the DMPK gene, causing myotonic dystrophy type 1 (DM1).

DOMINIKA DZIEDZICKA. Since September 2013. PhD project: Identification of molecular regulators of differentiation potential in human embryonic stem cells.

Graduated

LISE BARBE. Public defence 2017. PhD dissertation: Identification of molecular key drivers in disease development in myotpnic dystrophy type I

VEERLE GOOSSENS. Public defence 2015. PhD dissertation: Preimplantation genetic diagnosis. From bench to data collection. Co-promotor with Joep Geraedts en Sjoerd Repping

AFRODITI MERTZANIDOU. Public defence 2015. PhD dissertation: Chromosomal abnormalities in human preimplantation development. Co-promotor with Claudia Spits

KURT JACOBS. Public defence 2015. PhD dissertation: Genomic integrity of human embryonic stem cells: Low grade mosaicism and the effect of culture density. Co-promotor with Claudia Spits

LINDSEY VAN HAUTE. Public defence 2013. PhD dissertation: Human embryonic stem cells as a paradigm for disease modelling in respiration. Co-promotor Martine De Rycke

CHEN BING. Public defence 2011. PhD dissertation: Extracellular factors regulate pancreatic fate of human embryonic stem cells. Co-promotor with Luc Bouwens

ILEANA MATEIZEL. Public defence 2010. PhD dissertation: Human embryonic stem cells: challenges and novel approaches. Co-promotors Inge Liebaers and André Van Steirteghem

URIELLE ULLMANN. Public defence 2009. PhD dissertation: Human embryonic stem cell derivation and optimization of cultures: characterisation of epithelial-mesenchymal transition in feeder free cultures. Co-promotor with Inge Liebaers and Martine De Rycke

NELE DE TEMMERMANN. Public defence 2009. PhD dissertation: DM1 repeat instability in human gametes, embryos and embryonic stem cells. Co-promotor with Inge Liebaers

CLAUDIA SPITS. Public defence 2006. PhD dissertation: (R)evolution in preimplantation genetic diagnosis: development and clinical application of different approaches to preimplantation genetic diagnosis for monogenic disorders. Co-promoter with Inge Liebaers

 

Links to public databases

All Karen Sermon's publications can be found here:

ResearcherID

Web of Knowledge

Researchgate

All Karen Sermon's supervised masters and PhDs can be found here.

This includes PhD theses outside REGE where she was a jury member.

Recent publications

Gain of 20q11.21 in Human Pluripotent Stem Cells Impairs TGF-β-Dependent Neuroectodermal Commitment.

09/07/2019
Gain of 20q11.21 in Human Pluripotent Stem Cells Impairs TGF-β-Dependent Neuroectodermal Commitment. Markouli, C. , Couvreu De Deckersberg, E. , Regin, M. , Nguyen Thi, H. , Zambelli, F. , Keller, A. S. , Dziedzicka, D. , De Kock, J. , Tilleman, L., Van Nieuwerburgh, F., Franceschini, L. , Sermon,...

Iodine Dose of Administered Contrast Media Affects the Level of Radiation-Induced DNA Damage During Cardiac CT Scans.

23/04/2019
Iodine Dose of Administered Contrast Media Affects the Level of Radiation-Induced DNA Damage During Cardiac CT Scans. Van Cauteren, T. , Honorio Da Silva, E. , Van Gompel, G. , Kersemans, V., Sermon, K. , De Mey, J. & Buls, N. , 23 Apr 2019 , In : American Journal of Roentgenology...

Uncovering regulators of human embryonic stem cell differentiation bias towards definitive endoderm

20/02/2019
Uncovering regulators of human embryonic stem cell differentiation bias towards definitive endoderm Dziedzicka, D. , Tewary, M., Tilleman, L., Keller, A. S. , Östblom, J., Couvreu De Deckersberg, E. , Markouli, C. , Spits, C. , Van Nieuwerburgh, F., Zandstra, P., Sermon, K. & Geens, M. , 20 Feb...

In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors

30/11/2018
In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors Vanhauwaert, S., Decaesteker, B., De Brouwer, S., Leonelli, C., Durinck, K., Mestdagh, P., Vandesompele, J., Sermon, K. , Denecker, G., Van Neste, C., Speleman, F. & Preter, K. D., 30 Nov...

Gains of chromosome 12p results in failure to exit pluripotent state and reduced differentiation capacity during hepatic differentiation of human pluripotent stem cells

26/10/2018
Gains of chromosome 12p results in failure to exit pluripotent state and reduced differentiation capacity during hepatic differentiation of human pluripotent stem cells Keller, A. S. , Dziedzicka, D. , Kaçin, E. , Sermon, K. , Spits, C. & Geens, M. , 26 Oct 2018 .

Research...