Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage segregation in human preimplantation embryos
Regin et al. 2024, eLife...
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Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity
Krivec et al. 2024, Cell Death and Disease
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De Novo Cancer Mutations Frequently Associate with Recurrent Chromosomal Abnormalities during Long-Term Human Pluripotent Stem Cell Culture
Al Delbany et al., 2024, Cells...
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A heatmap for expected cumulative live birth rate in preimplantation genetic testing for monogenic disorders and chromosomal structural rearrangements
Van der Kelen et al., 2024 JARG...
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SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss
Lei et al. 2024, Stem Cell Reports...
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Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight
Mertens et al., 2024, Nature Communications...
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Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research
Krivec et al. 2023, Stem Cell Reports...
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An update on human pre- and peri-implantation development: a blueprint for blastoids
David et al. 2023, Current Opinions in Genetics & Development...
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ISSCR standards for the use of human stem cells in basic research
Ludwig et al. 2023, Stem Cell Reports...
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Lineage segregation in human pre-implantation embryos is specified by YAP1 and TEAD1
Regin and Essahib et al. 2023, Human Reproduction...
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A conserved role of Hippo signaling in initiation of the first lineage specification event across mammals
Gerri et al. 2023, Development...
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A systematic review and evidence assessment of monogenic gene–disease relationships in human female infertility and differences in sex development
Van der Kelen et al. 2022, Human Reproduction Update
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